Seizures after antiemetic treatment with high dose domperidone: report of four cases.

The judicious use of antiemetic treatment has made chemotherapy tolerable for a considerable number of patients.' As the dosage of antiemetic drugs is increased, however, so side effects-particularly in the central nervous system-are bound to increase in incidence and severity. We report the occurrence of seizures in four patients treated with high dose intravenous domperidone as prophylaxis against chemotherapy induced emesis.